Source: http://www.davenportcompany.com/blog/3315-s-gary-tulsa-ok-74105-1226710.html
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শুক্রবার, ৩১ আগস্ট, ২০১২
Long-extinct cousins' genetic mysteries revealed
MPIEA
Ancient DNA was extracted and analyzed using a novel sequencing approach.
By Alan Boyle
Degraded DNA molecules from a group of human relatives who went extinct tens of thousands of years ago have been reassembled using a new technique, yielding a genetic code for the mysterious Denisovans that meets the standard for modern humans.
The findings are based on samples drawn from 40 milligrams of ground-up bone from a Siberian girl's finger. They confirm what scientists saw in a much less detailed genetic sequence they produced a couple of years ago and address some of the deep questions surrounding the Denisovans. But they also raise a few new questions, including a basic one: Just how old was the sample they analyzed?
"The amazing thing is that we can sequence the whole genome to very high accuracy, but there is too little carbon in it to do a date," Svante P??bo, a genetic researcher at the Max Planck Institute for Evolutionary Anthropology, told reporters during a teleconference this week. P??bo is the leader of the research team behind a paper on the project, published online today by the journal Science.
The finger bone was found in southern Siberia's Denisova Cave during an excavation in 2008. That dig was aimed at untangling the genetic relationship between Neanderthals and modern humans, and bones representing both those species were indeed found in the cave. But the initial analysis of the finger-bone sample revealed a genome that was neither Neanderthal nor classically human. That tiny bone and two molars that were also found in the cave represent the only known specimens of the Denisovan race.
MPIEA
A replica of the Denisovan girl's finger bone sits on a pinky finger, providing a sense of scale.
Previous analyses of the Denisovan genome were considered merely a rough draft, doing no better than an average of 1.9 readings for every molecular base pair in the DNA, or 1.9X. In comparison, the latest analysis goes to a coverage depth of 30X, which is typical of whole-genome sequencing for present-day humans.
The accuracy was increased by taking short, degraded double-strands of DNA, which couldn't be analyzed ?the usual tools for gene sequencing, and "unzipping" them into single strands. That made it easier to attach specially designed molecules known as adapters and read out the DNA code, piece by piece.
"There are many things you can do with such a high-coverage genome that you cannot do with the low-quality genome that we had before," said Matthias Meyer, a colleague of P??bo's at the Max Planck Institute who developed with the new sequencing technique. Here are the main findings reported today:
- A comparison of chromosomes that the girl inherited from her mother and father indicated that there was surprisingly low genetic diversity in the Denisovan population. That would suggest that the Denisovan population never was very large, and could explain why the group faded into extinction as populations of modern humans spread out.
- Detailed study of the "gene flow" over time suggests that the Denisovans interbred with Neanderthals as well as our own species, Homo sapiens. The analysis confirmed previous findings that Denisovans were more genetically similar to Neanderthals than to anatomically modern humans. So does that mean that Denisovans were a separate species? "I really stay away from species designation," P??bo told reporters. "I would not call it a different species, but clearly different groups with a different history. I would not call the Neanderthals a different species from humans either, actually."
- A comparison of the genome with those of modern-day human populations confirmed that Melanesians, Australian Aborigines and other Southeast Asian islanders had the most in common genetically with the Denisovans. The Denisovan contribution to the genomes of present-day Papuans was estimated at 6 percent.
- A deeper analysis of the Papuan-Denisovan connection showed that the Denisovan contribution was lower for the sex-linked X chromosome than it was for other chromosomes. That might suggest that the Denisovan males were more likely than the females to interbreed with modern humans. Or it could mean there was a genetic defect on the X chromosome that led to its elimination from modern-day genomes.
- The researchers were able to triangulate, using the Denisovan genome as well as the genetic codes for Neanderthals and modern humans, to come up with an unexpected result: Present-day east Asians appear to have more in common genetically with the Neanderthals than present-day Europeans, even though Europe was thought to be the main hangout for Neanderthals hundreds of thousands of years ago.
- The researchers also drew up a catalog of more than 100,000 genetic differences that apparently arose between modern humans and the now-extinct Denisovans and Neanderthals in the past 100,000 years or so. About 260 of the changes affect protein function, P??bo said. "It is quite interesting to me to note that eight of them have to do with brain function and brain development ... and some of them have to do with genes that, for example, cause autism when these genes are mutated," he said. "So I think this is perhaps in the long term, to me, the most fascinating thing about this: what it will tell us in the future about what makes us special in the world, relative to Denisovans and Neanderthals."
Genetic sequencing alone can't tell scientists how long ago the Denisovans lived, however. P??bo and his colleagues factored in assumptions about the mutation rate of the human genome to estimate that the girl with the finger bone lived somewhere around 74,000 to 82,000 years ago. But a separate line of evidence, based on the rock layering in the cave, suggested that the bone was 30,000 to 50,000 years old.
"I'm very unsure about the archaeological dates, but I would say that I am equally unsure about our molecular dates," P??bo told reporters.
Similarly, the researchers give a wide range of dates for their estimate of the time when the Denisovan population split off from the evolutionary line leading to modern humans: 172,000 to 700,000 years ago.
"Most of the uncertainty in that number ... comes from the uncertainty at present about the human mutation rate," said another co-author of the paper, David Reich, a geneticist at Harvard Medical School and the Broad Institute. "There is a lot of debate in the community about the rate at which mutations accumulate."
Future studies, involving DNA analysis as well as carbon-dating analysis of other specimens from the Denisova Cave, may help clear up that uncertainty. But for the team behind the research announced today, an even higher priority is to generate a gene sequence for the Neanderthals that's as good as the sequence they now have for the once-mysterious Denisovans.
John Hawks, an anthropologist at the University of Wisconsin at Madison, said the newly published paper was "solid work."
"It's really neat that they've organized a catalog of things that humans have that are not present in this ancient genome," Hawks, who studies human origins but was not part of P??bo's research team, told me. He said the study of comparative brain genetics, for example, was becoming an increasingly important area, "and this study is part of it."
"We know that the human brain is a big target of evolution, but establishing the order of these changes is an important step now," he said. "This gives us a time stamp on some of those changes."
The technique developed for the Denisovan DNA could be applied much more widely in the future. Meyer said his method could be used on modern-day forensic samples that are too degraded to be analyzed using current techniques. And who knows? Anthropologists may find still more long-lost, extinct cousins in the fossil record whose genomes need to be done.
In addition to P??bo, Meyer and Reich, authors of the Science paper, "A High-Coverage Genome Sequence From an Archaic Denisovan Individual," include Martin Kircher, Marie-Theres Gansauge, Heng Li, Fernando Racimo, Swapan Mallick, Joshua G. Schraiber, Flora Jay, Kay Pr?fer, Cesare de Filippo, Peter H. Sudmant, Can Alkan, Qiaomei Fui, Ron Do, Nadin Rohland, Arti Tandon, Michael Siebauer, Richard E. Green, Katarzyna Bryc, Adrian W. Briggs, Udo Stenzel, Jesse Dabney, Jay Shendure, Jacob Kitzman, Michael F. Hammer, Michael V. Shunkov, Anatoli P. Derevianko, Nick Patterson, Aida M. Andr?s, Evan E. Eichler, Montgomery Slatkin and Janet Kelso.
Alan Boyle is NBCNews.com's science editor. Connect with the Cosmic Log community by "liking" the log's?Facebook page, following?@b0yle on Twitter?and adding the?Cosmic Log page?to your Google+ presence. To keep up with Cosmic Log as well as NBCNews.com's other stories about science and space, sign up for the Tech & Science newsletter, delivered to your email in-box every weekday. You can also check out?"The Case for Pluto,"?my book about the controversial dwarf planet and the search for new worlds.
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Early menopause: A genetic mouse model of human primary ovarian insufficiency
![[ Back to EurekAlert! ]](http://www.eurekalert.org/images/back2e.gif){kind=small}
Public release date: 30-Aug-2012[ | E-mail |
Share ] Contact: Quinn Eastman
qeastma@emory.edu
404-727-7829
Emory University
Scientists have established a genetic mouse model for primary ovarian insufficiency (POI), a human condition in which women experience irregular menstrual cycles and reduced fertility, and early exposure to estrogen deficiency.
POI affects approximately one in a hundred women. In most cases of primary ovarian insufficiency, the cause is mysterious, although genetics is known to play a causative role. There are no treatments designed to help preserve fertility. Some women with POI retain some ovarian function and a fraction (5-10 percent) have children after receiving the diagnosis.
Having a mouse model could accelerate research on the causes and mechanisms of POI, and could eventually lead to treatments, says Peng Jin, PhD, associate professor of human genetics at Emory University School of Medicine.
The results were published online recently in the journal Human Molecular Genetics.
The paper was the result of a collaboration between researchers at Emory and the Institute of Zoology, Chinese Academy of Sciences in Beijing. Dahua Chen, PhD, associate director of the State Key Laboratory of Reproductive Biology, is the senior author and postdoctoral fellow Cuiling Lu is the first author. Stephanie Sherman, PhD, professor of human genetics at Emory, is a co-author.
The mouse model builds on research on women who are carriers of a "premutation" for fragile X syndrome, a leading cause of inherited intellectual disability.
The mice have a fragment of a human X chromosome from a fragile X premutation carrier. Other non-genetic mouse models used to study menopause include surgical removal of the ovaries, or exposure of mice to a chemical, 4-vinylcyclohexene diepoxide, which depletes the ovaries.
"While the fragile X premutation is a leading cause of POI, I think this model will be useful and relevant for all women with this condition," Jin says.
Women with the fragile X premutation account for around two percent of spontaneous POI cases and 14 percent of familial POI cases. About 20 percent of women who carry the fragile X premutation experience POI, the disorder now called fragile X-associated POI, or FXPOI.
Fragile X syndrome is caused by the expansion of a "triplet repeat" in a gene (FMR1) that is important for signaling in the brain. In fragile X syndrome, the triplet repeat -- three DNA letters (CGG) repeated many times -- forces the gene to shut off.
For a woman who carries the premutation, the triplet repeat is not large enough to shut the gene off. There is a risk that it will expand in her children enough to generate fragile X syndrome. In addition, the triplet repeat appears to have an effect on the woman's ovaries, independently from its influence on the FMR1 gene.
Jin says studying mice that have an analogous genetic alteration will help scientists understand what's happening to the ovaries in POI. It appears that the RNA coming from the premutation impairs development of the ovarian follicles, the structures in which eggs/oocytes mature.
The research team found that a quarter of premutation-carrying female mice are infertile. When they are housed with male mice, those that do have pups have them a month later on average (12.5 weeks of age compared to 8.5 weeks), and they have fewer pups.
Puberty occurs at roughly five weeks of age in mice, and the premutation mice have alterations in their ovaries already before puberty. At 25 days of age, there are a reduced number of mature follicles in ovaries of the female mice carrying the premutation. Those mice also have altered levels of hormones resembling those of women with POI, such as elevated FSH (follicle stimulating hormone).
The research team found that in the ovaries of mice with the fragile X premutation, ovulation-related genes are less active. In addition, two cellular signaling pathways (Akt/mTOR) are less active in the ovaries, suggesting that drugs that affect those pathways could be used to treat POI.
###
The research in Jin's laboratory was supported by the National Institute of Neurological Disorders and Stroke (NS051630 and NS067461). Chen's laboratory is supported by the Chinese Academy of Sciences, the National Basic Research Program of China and the National Science Foundation of China.
Reference: C. Lu et al. Fragile X premutation RNA is sufficient to cause primary ovarian insufficiency in mice. Hum. Mol. Genet. (2012) doi:10.1093/hmg/dds347
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Public release date: 30-Aug-2012[ | E-mail |
Share ] Contact: Quinn Eastman
qeastma@emory.edu
404-727-7829
Emory University
Scientists have established a genetic mouse model for primary ovarian insufficiency (POI), a human condition in which women experience irregular menstrual cycles and reduced fertility, and early exposure to estrogen deficiency.
POI affects approximately one in a hundred women. In most cases of primary ovarian insufficiency, the cause is mysterious, although genetics is known to play a causative role. There are no treatments designed to help preserve fertility. Some women with POI retain some ovarian function and a fraction (5-10 percent) have children after receiving the diagnosis.
Having a mouse model could accelerate research on the causes and mechanisms of POI, and could eventually lead to treatments, says Peng Jin, PhD, associate professor of human genetics at Emory University School of Medicine.
The results were published online recently in the journal Human Molecular Genetics.
The paper was the result of a collaboration between researchers at Emory and the Institute of Zoology, Chinese Academy of Sciences in Beijing. Dahua Chen, PhD, associate director of the State Key Laboratory of Reproductive Biology, is the senior author and postdoctoral fellow Cuiling Lu is the first author. Stephanie Sherman, PhD, professor of human genetics at Emory, is a co-author.
The mouse model builds on research on women who are carriers of a "premutation" for fragile X syndrome, a leading cause of inherited intellectual disability.
The mice have a fragment of a human X chromosome from a fragile X premutation carrier. Other non-genetic mouse models used to study menopause include surgical removal of the ovaries, or exposure of mice to a chemical, 4-vinylcyclohexene diepoxide, which depletes the ovaries.
"While the fragile X premutation is a leading cause of POI, I think this model will be useful and relevant for all women with this condition," Jin says.
Women with the fragile X premutation account for around two percent of spontaneous POI cases and 14 percent of familial POI cases. About 20 percent of women who carry the fragile X premutation experience POI, the disorder now called fragile X-associated POI, or FXPOI.
Fragile X syndrome is caused by the expansion of a "triplet repeat" in a gene (FMR1) that is important for signaling in the brain. In fragile X syndrome, the triplet repeat -- three DNA letters (CGG) repeated many times -- forces the gene to shut off.
For a woman who carries the premutation, the triplet repeat is not large enough to shut the gene off. There is a risk that it will expand in her children enough to generate fragile X syndrome. In addition, the triplet repeat appears to have an effect on the woman's ovaries, independently from its influence on the FMR1 gene.
Jin says studying mice that have an analogous genetic alteration will help scientists understand what's happening to the ovaries in POI. It appears that the RNA coming from the premutation impairs development of the ovarian follicles, the structures in which eggs/oocytes mature.
The research team found that a quarter of premutation-carrying female mice are infertile. When they are housed with male mice, those that do have pups have them a month later on average (12.5 weeks of age compared to 8.5 weeks), and they have fewer pups.
Puberty occurs at roughly five weeks of age in mice, and the premutation mice have alterations in their ovaries already before puberty. At 25 days of age, there are a reduced number of mature follicles in ovaries of the female mice carrying the premutation. Those mice also have altered levels of hormones resembling those of women with POI, such as elevated FSH (follicle stimulating hormone).
The research team found that in the ovaries of mice with the fragile X premutation, ovulation-related genes are less active. In addition, two cellular signaling pathways (Akt/mTOR) are less active in the ovaries, suggesting that drugs that affect those pathways could be used to treat POI.
###
The research in Jin's laboratory was supported by the National Institute of Neurological Disorders and Stroke (NS051630 and NS067461). Chen's laboratory is supported by the Chinese Academy of Sciences, the National Basic Research Program of China and the National Science Foundation of China.
Reference: C. Lu et al. Fragile X premutation RNA is sufficient to cause primary ovarian insufficiency in mice. Hum. Mol. Genet. (2012) doi:10.1093/hmg/dds347
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Source: http://www.eurekalert.org/pub_releases/2012-08/eu-ema083012.php
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বৃহস্পতিবার, ৩০ আগস্ট, ২০১২
Kepler discovers planetary system orbiting 2 suns
Wednesday, August 29, 2012
Astronomers at the International Astronomical Union meeting announced the discovery of the first transiting circumbinary multi-planet system: two planets orbiting around a pair of stars. The discovery shows that planetary systems can form and survive even in the chaotic environment around a binary star. And such planets can exist in the habitable zone of their stars. "Each planet transits over the primary star, giving unambiguous evidence that the planets are real," said Jerome Orosz, Associate Professor of Astronomy at San Diego State University and lead author of the study which is published today in the journal Science.
The system, known as Kepler-47, contains a pair of stars whirling around each other every 7.5 days. One star is similar to the Sun while the other is a diminutive star only one third the size and 175 times fainter. The inner planet is only 3x larger in diameter than the Earth, making it the smallest known transiting circumbinary planet. It orbits the stellar pair every 49 days.
The outer planet is slightly larger than Uranus and orbits every 303 days, making it the longest-period transiting planet currently known. More importantly, its orbit puts it in the "habitable zone", the region around a star where a terrestrial planet could have liquid water on its surface. While the planet is probably a gas-giant planet and thus not suitable for life, its discovery establishes that circumbinary planets can, and do, exist in habitable zones.
Although much more difficult to detect than planets around single stars, the rich dynamics and wild climate changes make these circumbinary planets worth the effort to find. These two planets join the elite group of 4 previously known transiting circumbinary planets, Kepler-16, 34, 35 and 38.
The new planetary system is located roughly 5000 light-years away, in the constellation Cygnus. The planets are much too far away to see, so they were discovered by the drop in brightness they cause when they transit (eclipse) their host stars. The loss of light caused by the silhouette is tiny, only 0.08% for planet b and 0.2% for planet c. By comparison, Venus blocked about 0.1% of the Sun's surface during its recent transit. Precise photometric data from NASA's Kepler space telescope allowed the transits and eclipses to be measured, which in turn provided the relative sizes of the objects. Spectroscopic data from telescopes at McDonald Observatory in Texas enabled the absolute sizes to be determined. "Based on their radii, these probably have masses of approximately 8 and 20 times that of the Earth," Orosz said.
"Kepler-47 shows us that typical planetary architectures, with multiple planets in co-planar orbits, can form around two stars," said co-author Joshua Carter, a Hubble Fellow at the Harvard-Smithsonian Center for Astrophysics. "We've learned that circumbinary planets can be like the planets in our own Solar System, but with two suns."
The work was presented at the International Astronomical Union meeting by Dr. William Welsh, Professor of Astronomy at San Diego State University, on behalf of the Kepler Science Team.
"The thing I find most exciting," said Welsh, "is the potential for habitability in a circumbinary system. Kepler-47c is not likely to harbor life, but if it had large moons, those would be very interesting worlds."
###
San Diego State University: http://www.sdsu.edu
Thanks to San Diego State University for this article.
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Source: http://www.labspaces.net/123046/Kepler_discovers_planetary_system_orbiting___suns
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Michael Keaton Added To 'RoboCop' Cast
No matter how hard we try not to over-analyze it, this "RoboCop" reboot just keeps commanding our attention. And just when we think the multiple casting announcements will come to an end, we get a brand new one thrown at us. According to Deadline, Michael Keaton is set to play the role of Raymond Sellars, [...]
Source: http://moviesblog.mtv.com/2012/08/30/michael-keaton-robocop/
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NASA's Mars rover beams will.i.am song back to Earth (+video)
Broadcast from NASA's Curiosity rover, 'Reach for the Stars,' by rapper will.i.am, is the first human song ever played from Mars. ?
Entertainer will.i.am speaks to students as he debuts a new song in honor of Curiosity rover at JPL, Pasadena, Calif., on Tuesday
NASA TV
EnlargeThe first song ever played from Mars was broadcast today (Aug. 28) from NASA's Curiosity rover on the Red Planet.
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JPL and Will.i.am challenge young students to reach for the stars.The concert represented the world premiere of the appropriately named song "Reach for the Stars," by rapper and songwriter will.i.am. It was beamed via radio signal about 150 million miles (241 million km) back to Earth from Curiosity's landing spot on Mars' Gale Crater at 1 p.m. PDT (4 p.m. EDT).
"The point of the song is to remind people ? that anything is possible if you discipline yourself and dedicate yourself and stand for something," the musician said today from Curiosity's mission control center at NASA's?Jet Propulsion Laboratory?(JPL) in Pasadena, Calif.
The music arrived there during an educational event held for students from the Los Angeles neighborhood where will.i.am grew up.
"There's no words to explain how amazing this is," will.i.am. said. "These kids here are from Boyle Heights, the same neighborhood I'm from. We don't have to just end up in the 'hood. But it's a hard thing. The hardest thing is discipline."
Students and rocket scientists alike bobbed their heads and clapped as the song's strains came back to Earth.
"Why do they say the sky is the limit
When I've seen footprints on the moon
And I know the sky may be high
But baby it ain't really that high
And I know that Mars might be far
But baby it ain't really that far
Let's reach for the stars"
Also onhand at the event was former NASA astronaut Leland Melvin, now the agency's associate administrator for education.
"Never give up," Melvin said. "People told me that I couldn't be an astronaut. Whatever you want to be, whatever you dream, you can do, if you put your mind to it."
The $2.5 billion Curiosity landed on Mars Aug. 5 (PDT) after launching in November of last year. The song was loaded onto the rover before its departure from Earth, and will.i.am, part of the hip-hop group The Black-Eyed Peas, was at JPL in person to?watch Curiosity land.
The car-size rover is embarking on a two-year mission to search for signs that the Red Planet may have ever been?habitable to microbial life.
Follow Clara Moskowitz on Twitter?@ClaraMoskowitz?or SPACE.com?@Spacedotcom. We're also onFacebook?&?Google+.?
Copyright 2012?SPACE.com, a TechMediaNetwork company. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
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বুধবার, ২৯ আগস্ট, ২০১২
Modern Trends In Residential Roofing Nowg.Net - Home ...
You?ve seen metal rooftops on barns, but how often have you seen them on personal property? It?s very likely you?ll be seeing them a whole lot more around the country. With wildfires, serious weather, hailstorm and other dimensions harmful houses, many property owners are enjoying the advantages of metal roof structure. Steel roofing sets ups have more than doubled in the last five decades and will increase 15 % per season, according to the Metal Roofing Association (MRA). There is no material more capable of defending a house from dangerous circumstances. A metal roofing will last at least two to three times longer than a road roofing, or 40 to 60 decades. In the warm, moist Southeast declares, metal is virtually safe from the undesirable pattern spots that often form on road roof shingles. Effectively set up, a metal roofing won?t flow or corrosion and can hold up against wind flow squalls up to 140 mph. Shane Scott, a real-estate business owner from LaGrange, Atlanta, renovates and resells older houses. He set up a metal roofing in his own house in 2000 and was so pleased with it has purchased metal rooftops for all the houses he?s renovated since then.
?When buyers are considering a house, they?re always concerned about the condition of the roofing,? notices Scott. ?With metal, they know they won?t need to do anything to it for at least 50 decades. Most metal roofing systems have approved UL 2218 Effect Level of resistance examining at its most serious level, Class IV. As a result, property owners in hail-prone declares who choose a metal roof structure may be qualified for reductions in their expenses. Ed Parker, an outdated house owner from Sharpsburg, Atlanta confirms. ?We?ve gone through two or three road rooftops on our house over the decades and they tarnish and rip off during wind flow stormy weather, or flow due to hailstorm stormy weather,? Parker said. ?Metal is much stronger.? The National Organization of Contractors Research Center reports that 20 billion dollars pounds of road roof structure are taken to dumps every season. Metal?s strength eliminates the need for frequent roofing alternatives. Better still, it can be set over the current roofing, removing the expenses of shingle removal and landfill fees.
If a metal roof is ever eliminated, it can be reused. Steel is the best choice for ?green? structures, where the goal is to reduce or remove ingredients, according to the American Iron and Steel Institution (AISI). As opposed to wood made drinks or some other traditional materials, metal is not susceptible to bugs, pattern or rot. Therefore, it does not require the application of pesticides or other dangerous substances. Time-tested metal rooftops preserve power and reduce your chilling expenses by as much as 40 %, based on location, says the MRA. The introduction of new indicative shows with energy-saving qualities has totally changed the personal roof structure industry. While road and cedar plank roof shingles process warm, the new awesome color technology can indicate up to 85 % of the sun?s glowing power. Now, even darker shades are achieving the ?cool? features. An Energy Celebrity roofing can stay up to 100 levels chillier on its surface than other rooftops, so less warm is relocated into the developing.
Source: http://www.nowg.net/modern-trends-in-residential-roofing/
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Save 50? on any one (1) Baby Mum-Mum? or Toddler Mum-Mum ...
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মঙ্গলবার, ২৮ আগস্ট, ২০১২
Simple Steps To Getting Started In Commercial Real Estate ...
Success as a commercial real estate broker can happen to anybody; many people have done it. Success in real estate is not an exact science. What is needed is industry-related knowledge, experience, and much hard work. This article has much advice on beginning a career in commercial real estate.
Find out how to spot and jump on good deals. Good deals are easily recognized by real estate professionals. Their secret entails that they have an exit strategy, meaning that they know when to walk away from a deal. They have also developed a good feel for what types of deals are riskier than others, how expensive certain types of repairs will be, and how to balance repair costs against long-term profit.
When considering commercial real estate, you should think about the importance of honing relationships with private investors. Remember that many properties sell before they can even be listed; therefore, a more complete network improves your chances of locating the best opportunities.
Creating your own real estate blog can help to establish you as an expert in the field. Doing so can assist you in finding buyers and renters for your properties.
Educate yourself on the meaning of net operating income (NOI), a term associated with commercial real estate used for investment purposes. For the investment to be profitable, it has to produce more income than operating expenses.
When considering an investment, one should consider the possible consequences of economic inflation within the next decade. Investors in the past were protected by a clause that was built into any agreement that adjusted for inflation using Consumer Price Index comparisons. This generally doesn?t happen anymore, so unusually high inflation could cause unexpected losses.
You should be aware of any environmental concerns. A major area of concern would arise if the property has a history of hazardous waste generation or disposal issues. Once you purchase a commercial property, hazardous wastes and environmental issues become your problem.
Make sure you always remain cool, calm, and collected when you begin to look for commercial real estate. Do not invest into anything before thinking carefully. A poorly thought out investment might soon give you many regrets. It could take as long as a year to find the right investment in your market.
Invest in real estate that has a large number of units. If there are many units, it would be easier for you to spread the income that you are getting from each unit. Many purchasers will not even glance at a property if it has less than ten units, and most believe that the more units included, the more money you can make.
Take into consideration the local unemployment levels, average income, and job market before investing in real estate. If you?re house is close to a university, hospital, or large employment center, they sell quick and at increased values.
Find out how different real estate agents negotiate before you choose one. Inquire about their training and experience. Make sure they are knowledgeable about finding good deals and that they are ethical in all their business dealings. Inquire about any past negotiations, both good and bad, that they can show you.
If you know how to go about it, you can achieve success in the commercial real estate industry. Keep the tips in this article handy in order to effectively apply them to the work your business does. Constantly look for ways to learn more about commercial real estate, and identify strategies you can utilize to improve. With experience you will be more
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Save the Date: Art Meets Fashion (AMF) at Red Butte Garden ...
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WHAT: Now in its fourth year, the annual event?combines the best of local art and fashion. The glamorous, edgy evening (guests are encouraged to dress in ?black tie alternative??think a deconstructed tux or an LBD with funky accessories) features runway shows, exhibitions, performances, and food and wine pairings. This year, ticket sales from the artsy affair benefit the new Water Conservation Garden at Salt Lake City?s Red Butte Garden.
During the event, four local fashion designers are set to premiere full collections: Beckett & Robb (a Salt Lake/Park City Bride & Groom favorite!), Sophie St. Claire, Nephi Garcia, and Heggy Gonzalez.
The evening spotlights an exhibition of 15 fine artists?titled Metamorphosis, including painting, mixed media, and photography by artists Shelly Hunyh (who you may know as the owner of Orchid Dynasty, another SLPCBG favorite!), Cody Chamberlain, Mark Crenshaw, Blake Palmer, Jon Lang, Zuzanna Audette, Chase McCleary, Jenevieve Hubbard, Susan Ferguson, Silvia Solis, Jimmi Toro, Matthew Potter, Todd Powelson, Nanette Wiser, Alexander Ferguson, and David Marshall Habben.
Eat and drink at artistically inspired tasting stations in The Art of Food & Wine lounge, presented by Southern Wine & Spirits West and eight local restaurants including Cannellas, Amore, Dojo, So Cupcake, Brio Tuscan Grill, and more.
WHERE: Red Butte Garden (300 Wakara Way, SLC). Runway shows take place on the garden pathway in the Rose and Wedding Gardens, and the fine art exhibition is on display in the Rose House Plaza. The evening concludes with a swing band performance and dancing on the amphitheater stage.
WHEN: Saturday, September 8 from 6 to 10 p.m. Tickets are $50 for regular admission (includes admittance to the gallery exhibition, fashion shows, and a selection of food and beverages), $100 for VIP (also includes reserved front row seating, a tour backstage, and tickets to the VIP night September 6), and $35 for students (must have a valid school ID; limited to two tickets per ID). Visit ArtMeetsFashion.net to purchase tickets and learn more about the event.
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Cops: Md. school suspect had 21 rounds of ammo
Baltimore County Police Department / AP
Robert Wayne Gladden, Jr., 15, of Baltimore.
By NBC News staff and wire services
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PERRY HALL, Md. - A 15-year-old sophomore at a suburban Baltimore high school who made references to murder-suicide on Facebook has been charged as an adult in the shooting of a classmate on the first day of school, authorities said Tuesday.
Robert Wayne Gladden Jr. was being held without bail on charges of attempted first-degree murder and first-degree assault, Baltimore County police said. A preliminary hearing was scheduled for Sept. 7. The state's attorney's office said it?did not know if he had a lawyer.
Gladden's last status update on his Facebook page, posted the morning of the shooting, read: "First day of school, last day of my life. ... f--- the world."
A 15-year-old Maryland gunman was charged as an adult after he shot and critically wounded another student at their local high school. WRC's Pat Collins reports.
His father told The Associated Press that his son had been bullied. Baltimore County Police Chief James Johnson said at a news conference Tuesday that he was aware of the reported bullying, but he said Gladden has not indicated in conversations with detectives that bullying was a motive for the shooting. His father did not disclose other possible motives.
Gladden continues to cooperate with investigators and was undergoing a mental health evaluation, Johnson said.
Gladden rode to school on the bus Monday morning with a bag containing a disassembled shotgun, 21 rounds of ammunition and a bottle of vodka, Johnson said.
Steve Ruark / AP
A Baltimore County police officer speaks to a parent as students are evacuated from Perry Hall High School after a student was shot and critically wounded on the first day of classes on Monday, Aug. 27.
When he arrived at school, Gladden went to his first two classes, Johnson said. On the way to the cafeteria, he stashed the bag with the shotgun in a restroom, the chief said. A short time later, he returned to the restroom and assembled the gun, which he then hid beneath his clothes, Johnson said.
Previous report: Student shot at Maryland high school on first day of class
Upon entering the cafeteria, he pulled out the gun and fired a shot toward a lunch table, according to charging documents. A 17-year-old classmate, Daniel Borowy, was struck in the back.
Borowy is a special needs student, according to NBC affiliate WBALTV.com.?He remained in critical condition Tuesday at Maryland Shock Trauma Center, a hospital spokeswoman said. His family issued a statement asking well-wishers to keep him in their thoughts and prayers and asking for privacy.
Teachers and school staff rushed toward Gladden, and in the ensuing struggle, he fired another shot that hit the ceiling, investigators said in the documents. The staffers were able to get the gun away from him and he was arrested by a school resource officer.
Witnesses credited guidance counselor Jesse Wasmer with getting the gun away from Gladden.
Gladden sipped from the vodka bottle before the shooting but did not drink enough to become intoxicated, Johnson said.
The teen got the shotgun from his father's house, Johnson said. The weapon was manufactured before 1968 and was of legal length, and police were trying to determine whether it was properly registered, he said.
On his Facebook page, Gladden referred to mass murderer Charles Manson and gave himself the nickname "SuicidalSmile." The page, identified by classmates as belonging to the suspected shooter, was just launched in July, and the three photos of Gladden all show his face hidden behind long, dark hair. He describes himself as a "metalhead" and a fan of musicians Marilyn Manson and Slipknot.
The suspect's father, Robert W. Gladden, told the AP Monday evening that his son was the shooter and indicated his son had been bullied. He gave no further details.
A woman who was also at the home in Middle River and said she was related to the elder Gladden gave the following statement on the family's behalf: "We are horrified. We did not see this coming and our thoughts and prayers are with the victim and the victim's family."
Court documents show Gladden's parents divorced in 2010, reported WBALTV.com. The news station?went to the house where Gladden lives with his mother on Monday afternoon; a sign on the door read "We don't call 911," and had a picture of a revolver on it, reporters said.??No one in the house would comment on the shooting.
Police also executed a search warrant at the Kingsville home of Gladden's mother and stepfather and arrested the stepfather ? Andrew Piper, 43 ? on illegal gun and drug possession charges, police said. The charges against Piper had nothing to do with the school shooting, Johnson said, but he noted that Gladden lived part-time at that address.
Classes resumed Tuesday at the school amid a low-key police presence. About 150 students turned out for a prayer vigil organized by local churches on the school grounds. Some students wore T-shirts and bracelets reading "Pray for Daniel" and "Team Wasmer" in reference to the victim and the guidance counselor.
Shane Boyer, 44, who was dropping off his 13-year-old daughter Corinne, said the vigil helped calm students still dealing with the shooting. Boyer said he knew immediately that his daughter was safe after the shooting because he received text messages from her. One read, "Someone just shot a gun in lunch," followed by another that said, "I ran out I am do (sic) scared there's helicopters + cops + we are all outside."
Perry Hall is a middle-class community along the Interstate 95 corridor, northeast of the city of?Baltimore. The school is the largest in the county, with 2,200 students.
The Associated Press contributed to this report.
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What You Should Know About Adderall ... - Health and Fitness Blog
Adderall is a medicine prescribed to those enduring ADHD. Nevertheless, those that do not have this condition typically abuse this prescribed medicine. Those that are generally identified to have Adderall dependency are students (both highschool and college pupils) and athletes. The reasons that result in abuse are many and lots of abusers will definitely start due to the fact that of various causes: peer influence, help from pals or individuals that these people may look up to in the culture, amongst additional causes. Some parents will certainly introduce their kids to the utilization of Adderall as a procedure of enhancing their grades or performance in athletics.
The drug is offered in two methods one described as the instant release and the additional the extended release. The extended release is typically approved clinically for just those that are identified by having narcolepsy or with attention deficit and hyperactivity ailment. As aforementioned the medication is extremely addictive and the tragedy is that the accessibility of the medicine is shockingly easily accessible to countless making Adderall compulsion so extensive.
The issues with Adderall dependency are common among all people. Over time the customers need larger volume of drugs to get the experience or kind of consequence, which was initially obtained, with lesser quantity. This commonly leads the individual seeking new means of getting the excess volume of medicines needed to complement the volume suggested. Physician searching and acquiring the additional materials from black market are among some of the frequent techniques that are commonly made use of in complementing the added products called for.
Many people who have certainly established an Adderall dependency have actually come to be addicts from the start. No one presumes such long term effects because they figured that as soon as they achieve just what they set out to do (test or venture or event) they ?will immediately cease utilizing. Typically this is not the case and many people will be not able to stop making use of this medicine. However, this does not suggest it\?s inconceivable to overcome an Adderall dependency. Those by having tough sufficient self-control are able to stop completely and get clean. This is not a cause to start using these medicines since everybody is constructed in a different way and the circumstances surrounding individuals are different.
Those having an Adderall addiction sleep a whole lot less-with some sleeping for only 2 hrs. This may ultimately and ultimately additional impact the brain\?s functionality. The brain is currently being overworked by broadening the restrictions to which the mind can operate. The most sure-fire way to prevent this is to not utilize the medication at all but a lot of people are already past that point for that reason looking for qualified assistance is the greatest course of action to take. Do not seek to alleviate the addiction by having by making use of one more drug this will only make things worse yet. Lots of medication abusers may resort to this to counter to the withdrawal symptoms they are facing. For example an Adderall abuser will definitely take alcohol to counter withdrawal symptoms from Adderall use. This is merely an alternative and may just bring the abuser more suffering.
Adderall abusers ought to try rehabilitation programs or seeking help from drug and liquor counselors in order to begin on the path to recovery. These programs are designed to cater for abusers by competent personnel and candidates really should put utmost trust in them.
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Source: http://www.reardenconference2007.com/what-you-should-know-about-adderall-addiction
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Video: Bush: Obama?s policies have failed
A Second Take on Meeting the Press: From an up-close look at Rachel Maddow's sneakers to an in-depth look at Jon Krakauer's latest book ? it's all fair game in our "Meet the Press: Take Two" web extra. Log on Sundays to see David Gregory's post-show conversations with leading newsmakers, authors and roundtable guests. Videos are available on-demand by 12 p.m. ET on Sundays.
Source: http://www.msnbc.msn.com/id/3032608/vp/48794250#48794250
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Turtle Bay - Restaurant Review | DonkeyFodder.Com
Trini Fish Curry
My friends, Paul and Susie, are about to have there second child, in fact the baby due date is tomorrow (Monday 27th August). I haven?t seen them for a while and so decided to visit them in Milton Keynes, an area known for it?s plastic cows, actually they are concrete as I was forcibly reminded (lol hahaha) and lots of roundabouts. When I arrived we went to Mortimer Square which is an area surrounded by restaurants, most of them chains, like Caf? Rouge, Las Iguanas. We were trying decide where to go but as Susie was almost due it was decided not to have anything spicy, just in case. After looking around for a few minutes it was decided to go to The Turtle Bay, a Caribbean restaurant, odd choice, seeing as Caribbean is renowned for being spicy, but I wasn?t one to argue as I love spicy food.
We entered the large restaurant which was surrounded by large windows and because it was sunny the restaurant had warm and bright feel. In the centre is a large style wooden shack bar which all the tables surrounded. The tables and chairs are all wooden which add to the rustic feel, but it does have a feel of a restaurant chain in the making. When I checked out there website I saw they have another restaurant in Southampton, so I was right a new chain in the making.
Salt Cod Fritters
The menu is extensive with Cutter (starters), Lunch and Lighter (lunch menu or lighter bites if you don?t want a full meal. One Pots, (dishes that comes in a pot ? bet you didn?t see that coming). And Jerk Pit BBQ (dishes from a BBQ with Caribbean flavours). They also have a large array of both alcoholic and non-alcoholic cocktails which are on an almost continuous happy hour of 12-7pm and 10pm-close every day.
Jerk Chicken Wings
I guess they don?t see themselves as a family restaurant as they don?t have a child?s? menu. If you do take a young child in with you it appears that if you don?t want spicy food for your child you need to order a meat dish and ask for the spicy not to be added. We ordered a duck wrap, for little Henry and asked for no spice as advised, but when it arrived it was still fairly spicy..
Jerk Chicken Roti
Myself and Susie order fritters, I ordered the salt cod fritters and she ordered the sweetcorn fritter. They were not what we were expecting, they were more like savoury doughnuts rather than fritters. Also my fritters had virtually no salt cod in them and in fact I pulled them apart and only found one very small piece in each of the four fritters. The sweetcorn had more flavour but again more doughnut than fritter. Paul ordered the jerk pit chicken wings, which were very tangy and with a kick, the meat was moist and well cook and I certainly had food envy.
Sweet Potatoe Fries
After a disappointing starter and a slow removal of out plates and a far wait for our main courses our mains were delivered and we were not disappointed. I ordered the Trini Fish Curry, which was salmon, prawns, mussels, squid and white fish in a gorgeous curry spiced coconut milk. The rice and peas were well cooked and complimented the curry wonderfully. Paul ordered the Blue Mountain Curried Goat was also very tasty, the meat was tender and the curry sauce full of flavour, but with one little moan of not enough sauce, but fully enjoyed. Susie ordered Jerk Chicken Roti, which was pulled jerk chicken in a flat bread wrap which was moist with a hot kick. But not over spicy so the baby did not kick in objection or even worse, decide to show his/her face 
Curried Goat with Rice & Peas
We also had some side dishes, which I didn?t mind paying extra for as the main courses were reasonably priced. We ordered fried plantain, which were well cooked with lots of sweet flavour. We also ordered Sweet Potatoes Fries, there were delicious if a little greasy, but one of the highlights for me, seeing as I didn?t think sweet potato would work as a ?chip?, but it?s nice to be proved wrong.
Now I don?t normally review drinks, but as it was a cocktail bar and as Susie couldn?t drink, Paul and I decided we should try as many cocktails for her. So that she knew which cocktail tasted the best and to order once the baby was born. Well it was the only excuse we could come up with to allow us to try as many as we could. We tried the classic Long Island Ice Tea, which was the best. Jamaican Mule, okay, but the ginger beer wasn?t strong enough. Elderflower Collins which was fresh with lemon juice and club soda. Mojito, which had far to much ice so at the end we were drinking cold water and we finished off which Tropical Rum Punch which was okay, but we didn?t like the allspice syrup, which I thought would be nice with rum, but for us didn?t work.
The staff were very friendly and polite and couldn?t really fault them. But if I was to grumble, which means I will, they were a little too over enthusiastic. When we sat down, one waiter took our drinks order and then before the drinks came three other members of staff came over to take our drinks order. It was like that for the rest of the meal, but then when we wanted them there were hard to track down. I wonder if I am moaning for the sake of it, because as I said they were friendly and were very good with baby Henry.
For a small chain, I believe the Turtle Bay has a lot going for it and hopefully they will be a great success. I just hope they don?t go like other chains that as they become popular they expand too quickly and they lose there charm and the food starts to really suffer. I can think of two chains that at the beginning were very good, but I wouldn?t go near now as the food has really suffered. So fingers crossed for them and I would love to see one in London.
Source: http://donkeyfodder.com/turtle-bay-restaurant-review/
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Big Bang Art Fair - BizWestMichigan Artist/Entrpreneur Interviews ...
The Big Bang in The Center Of The Universe!
Rob Trube breaks with the normal format (again) to interview local entrepreneurial artists at the Big Bang Art Fair at Mangiamo?s on Lake Drive, at the ?Center of the Universe?. Local (and famous) artist Reb Roberts is the organizer of the 1st annual festival! We learn about the concept of the art fair, and a bit about the local art industry.
Rob also interviews several of the artists and attempts (at least he tried?) to showcase some of the art.
The local art industry is doing well, and is growing, and with these creative artists/entrepreneurs, you can see why!
We also learn about ART IT UP ? the kids art competition that is taking place during ArtPrize!
The Big Bang Art Fair is on Saturday and Sunday, 8/25 ? 26, 2012 at Mangiamo?s at 1033 Lake Drive SE. ?(Thanks to The Gilmore Group for allowing the use of the lawn for such a great event!)
You can learn more about the artists and their businesses by visiting their sites!:
Reb Roberts, Sanctuary Folk Art
Jeff Genderen, URAWAKE (pronounced yur-ah-wah-key)
Mark Bird, Bird Design
Farrer Coston, FarrerCoston
Jerry Berta, JerryBerta ? Digitally Enhanced Art?and Art It Up
John Guertin, Barns Into Birdhouses
Heather Robinson, Paper Peacock
Matt Voight, Matt Voight Wood Art
Amber Gerard, DayDream Studios
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Here is where it is!
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শনিবার, ২৫ আগস্ট, ২০১২
UPDATE 5-US Anti-Doping Agency strips Armstrong of titles for cheating
* "Enough is enough", says seven-time Tour de France winner
* Debate begins on whether cyclist is guilty
* Endorsement opportunities in question
Aug 24 (Reuters) - Lance Armstrong was stripped of his
record seven Tour de France wins and handed a lifetime ban by
the United States Anti-Doping Agency on Friday, but he remained
defiant as supporters rallied around the American cyclist.
Saying that "enough is enough," Armstrong issued a statement
late on Thursday indicating that would not challenge USADA
charges he had doped throughout his career, although he
continued to deny he had ever used performance-enhancing drugs.
While the USADA can remove Armstrong's titles, such a
decision could ultimately rest with the Court of Arbitration for
Sport in Lausanne, Switzerland, should the International Cycling
Union challenge the USADA's ruling.
But weary from years of denial, legal battles and skirmishes
with former teammates and anti-doping chiefs, Armstrong said it
was a fight he no longer had the stomach for.
"Today I will turn the page," Armstrong said. "I will no
longer address this issue regardless of the circumstances."
Less than 24 hours after issuing that statement, Armstrong
was planning 'business as usual' with a weekend bike ride in
Colorado, tweeting: "Excited to be racing the #poweroffour
tomorrow here in @AspenCO. 9000 vert in just 36 miles!"
Armstrong may have turned the page but the story is far from
over.
One of the sporting world's most polarizing figures,
Armstrong remains a hero to millions of cancer survivors for
beating the disease and coming back to win the Tour de France
seven times. To others, he is a drug cheat and fraud.
World Anti-doping Agency chief John Fahey said Armstrong's
decision not to contest the allegations added up to nothing more
than an admission of guilt.
"He had the right to rip up those charges, but he elected
not to. Therefore the only interpretation in these circumstances
is that there was substance in those charges," Fahey told
Reuters in a telephone interview on Friday.
Bill Stapleton, Armstrong's agent for 17 years, strongly
disagreed.
"This is not an admission of guilt, this is a rebuke of a
process that is disgusting and unfair," Stapleton said. "We
believe they're completely out of bounds.
"We've been clear that we don't think they (USADA) have the
authority to do that and we'll see what the people who run the
Tour de France and the International Federation of Cycling have
to say about that."
The debate over Armstrong's guilt will now rage, with some
heavy hitters like longtime sponsor Nike, the world's biggest
sportswear maker, lining up alongside the disgraced cyclist,
while anti-doping crusaders claim victory.
Since 2004, Nike has helped Livestrong, Armstrong's
organization to help cancer survivors, raise over $100 million
for cancer research and created the Livestrong yellow wristbands
that became a global phenomenon with over 84 million bands
distributed.
CONTROVERSIAL CYCLIST
"Lance has stated his innocence and has been unwavering on
this position. Nike plans to continue to support Lance and the
Lance Armstrong Foundation, a foundation that Lance created to
serve cancer survivors," the company said in a statement.
Armstrong, 40, has been one of the most successful and
controversial cyclists of all time, returning to the sport after
beating cancer to win the Tour de France seven straight times,
from 1999 to 2005.
Livestrong takes its inspiration from his achievements and
recovery from testicular cancer that made him a hero to many and
boosted the sport's popularity in the United States.
The Lance Armstrong Foundation, which raised $51 million in
2011, said it received 400 donations totaling $75,000 on Friday,
20 times more than the amount donated on Thursday.
Armstrong also made many enemies throughout his career, with
several of his former teammates and colleagues allegedly ready
to testify that he doped.
Former teammate and deposed Tour de France winner Floyd
Landis accused Armstrong in 2010 of using performance-enhancing
drugs and teaching others how to avoid being caught.
In a bizarre coincidence of timing, Landis appeared in
federal court in San Diego, California, on Friday and entered a
deferred prosecution agreement in which he admitted defrauding
1,765 individuals who donated money to the Floyd Fairness Fund.
The cyclist agreed to pay $478,354 in restitution.
Armstrong also has his loyalists, such as Jim Ochowicz,
director of the BMC cycling team and a longtime friend who
helped him when he was an amateur rider and young professional.
"As a friend of Lance's, I support his decision to call it
an end," said Ochowicz. "He has done so much for our sport over
the years, and I am sad at what has transpired.
"I love him. I know he still has a big fight ahead of him
and his battle of trying to find a cure for cancer and help
survivors and carry on with the Lance Armstrong foundation.
"I think he has earned every victory he's had," he said.
The USADA believes, however, it has enough compelling
evidence to prove Armstrong did not claim his victories fairly.
A quasi-governmental agency created by the U.S. Congress in
2000, the USADA formally charged Armstrong in June with doping
and taking part in a conspiracy with members of his championship
teams.
EVIDENCE AGAINST ARMSTRONG IN HAND
The agency said in a letter to Armstrong that it had blood
samples from 2009 and 2010 that were "fully consistent" with
doping.
Michael McCann, an expert in sports law at Vermont Law
School, said Armstrong's decision not to contest the USADA
charges in arbitration might have been the cyclist's best option
in the face of mounting circumstantial evidence.
"This gives his supporters reason to support him," McCann
told Reuters. "If he had gone to arbitration and lost - which I
think almost definitely would have happened - from a public
relations standpoint, that would have been much more harmful."
In losing his titles, Armstrong joins Canadian Ben Johnson
and American Marion Jones as the highest-profile athletes to
lose championships as a result of doping sanctions.
Johnson was stripped of the 1988 Seoul Olympics 100 metres
title after testing positive for a steroid. while Jones lost her
2000 Sydney Olympics 100, 200 and 4x400 metres relay gold medals
when she confessed she had been taking drugs at the time.
Armstrong faces the possibility of legal action from
promoters and race organizers looking to recover prize money.
It also remains to be seen what impact the USADA's action
will have on his endorsement potential and ability to keep
raising funds for his foundation.
Despite having his reputation tarnished, Armstrong's triumph
over cancer and fundraising efforts make him a valuable
pitchman, marketing experts said.
While Nike was quick to stand by Armstrong, his other
sponsors, including RadioShack, exercise bike maker
Johnson Health Tech, sunglass maker Oakley, owned by
Italy's Luxottica, and Michelob, made by Anheuser-Busch
InBev, have not leapt to his defence.
Robert Boland, professor of sports management at New York
University, said Armstrong's extensive work on cancer would
help blunt the impact of the lost titles.
"His story has not been diminished. Here's a guy who
essentially was at death's door with cancer and came back. That
example still makes him very compelling," he said.
Still, Boland said it would be difficult for Armstrong to
continue to endorse bicycles or bicycle equipment, since he is
now banned from competitions.
"If he can't show up at certain events, how do you use him?"
With the possibility each of his seven Tour de France crowns
could go to other riders, Armstrong maintained that no matter
what the USADA had ruled, those he competed with would always
know he was the true winner.
Spain's Fernando Escartin, who will rise to second from
third in the 1999 Tour de France after the USADA's decision,
said the American would always be the champion.
"For me, Lance Armstrong remains the 1999 Tour winner,
second (Alex) Zulle and third, me," the now-retired Escartin
told Reuters at the Vuelta a Espana race on Friday.
"It's 13 years now since this all happened. It seems
completely illogical and unreal. I don't want to even think
about it."
Source: http://news.yahoo.com/5-us-anti-doping-agency-strips-armstrong-titles-001800956--sector.html
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Modern Sliding Doors Come In Many Forms
Many people enjoy the idea of installing sliding doors in their home.? There are many different ways that people can use modern sliding doors.? There are also many different types of sliding doors that they can choose from.? Sliding doors can be used on both the interior and the exterior of the home.
On the interior of the home, the most popular use for sliding doors is in closets.? These doors do not infringe on the space in a bedroom as much as traditional hinged doors do.? They also allow for a wider access to the closet.? A person can choose sliding doors that work on tracks or they can choose bi-fold sliding doors.? The material the sliding door is made of is another choice that people can make.? Many people choose to have mirrored sliding doors.? These types of modern sliding doors can make smaller rooms appear much larger.? The most economical sliding doors are made out of wood and a person can easily install them without the help of a professional contractor.
People can also use modern sliding doors on the interior of their home to help divide different rooms.? The idea of an open concept is very popular in homes today, but if a person has modern sliding doors they can have the open concept when they want it and can create smaller, more intimate spaces by closing the sliding doors.? The most popular type of modern sliding doors for this purpose is the pocket doors.? These allow the sliding doors to stay hidden when they are not in use.
In the bathroom a modern sliding door can enclose a shower tub and keep the bathroom floor much drier than a shower curtain does.? This is another project that the home do-it-yourselfer can undertake as a weekend project.
Modern sliding doors are very good for the exterior of a home as well.? They allow people to connect the outdoor and indoor space of a home.? People usually see modern sliding doors that open up to a patio.? It has become very popular to have a sliding door that completely opens up to the backyard to create a continuous space from the home to the patio.? For people who live in warmer climates this provides them with more living space for much of the year.
Whenever a homeowner has sliding doors on the exterior of the home, they should take a few steps to make sure the doors are safe and secure.? Simple things like putting stickers on the windows of the modern sliding doors so that people know when the door is closed can help prevent accidents from happening.? Curtains can give a person the privacy they want at times when used with the sliding doors.? Dead bolts and slide bars can make sure that the doors are safe from intruders.
If a person is interested in seeing what kind of modern sliding doors are available, a trip to the local home improvement store would be a wise decision.? These stores have a selection of many different modern sliding doors for both interior and exterior purposes.? They also have people who can provide the expertise that a person will want to tell them how the different types of doors work and where they can be used in a home.
In case you need a new sliding door (or as we call it in Sweden nya skjutd?rr) make sure you pay a visit to this website for the best prices.
Source: http://door.ezinemark.com/modern-sliding-doors-come-in-many-forms-7d3663c75024.html
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শুক্রবার, ২৪ আগস্ট, ২০১২
Collect Information Ahead of Marketing Your Real-estate ...
When you find yourself a terrain owner, a significant part of your individual internet well worth can be tied up up within that home. For this reason, once you make the decision to offer it, you must seek the greatest promoting price you can perhaps get to your home. Providing you have the drive and also the self-discipline to understand the principles of marketing real estate property, you ought to have no difficulties choosing a purchaser for your property.
Freshen the residence prior to deciding to open up your home for looking at by potential customers. Clean your carpets, provide the surfaces a lick of fresh paint, and in case essential, get yourself a specialist cleaning services to strong fresh the full residence. Placing extra cash into correcting in the residence can certainly make it get noticed and definitely worth it in the end.
Make certain your home?s rooftop is in top condition just before attempting to promote your house. A roof structure which is wanting major maintenance could be a major package-breaker for buyers. In case you haven?t mended your rooftop ahead of your own home will go in the marketplace, it may be an incentive to provide possible buyers some financial allowance to alter for your reality.
Understand that real estate property revenue and acquisitions can be quite perplexing and time-taking in, and you will definitely decrease your required degree of effort by working with a real-estate company. There are many of sources that can help dealers manage the offer, it often brings about a lot less profit.
Straightforward purchases, for example new color, can help you in promoting your house. Execute a stroll-through of your overall property or home looking for everything that is displeasing towards the eye. You must also placed away modest kitchen appliances after you make use of them. Though it?s simple, it could create your counter room seem smaller.
Suppress attractiveness is actually a major aspect in whether or not buyers will stop to look at your property. Taking care of the plants allows customers see the outside of the home better once they very first pull up to it. Furthermore, it definitely makes the home appearance handled and well-held. A lot of consumers will enable their initially impression of a property impact their final decision.
With any fortune, you may have found some tips right here that is useful to you. It is important, obviously, to custom fit the info to the specific conditions. Consuming a while for more information about real estate property is an effective investment which will maximize your profits.
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Source: http://blog.ilove3c.com/2012/08/25/collect-information-ahead-of-marketing-your-real-estate/
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